About Alta Biotech

Alta Biotech, LLC is a fast-growing global contract research organization specializing in molecular biology, biochemistry and cell biology services. Our core area of expertise includes plasmid DNA purification, gDNA and total RNA extraction, gene synthesis and a wide portfolio of customized fundamental life science research support. With facilities located in the heart of the Fitzsimons Life Science District in Colorado, Alta Biotech has developed a variety of in-house technology platforms to provide fast, high-quality, and cost-effective services to exceed customer expectations. Our goal is to serve as a trusted bioscience partner to our customers.

 

about-usimage

Client Testimonials

“I most highly recommend Alta Biotech LLC for DNA prep services. For the last three years, Alta Biotech has been supporting our small to mid-scale protein production projects by supplying us with DNA prep services. The quality, delivery time and price have been exceptional for every order we have placed. Every DNA received from Alta Biotech has worked flawlessly without having to repeat transfections due to sequence confirmation. Additionally, sequence confirmation documentation supplied with each request can be easily managed to support internal compliance records.
Alta Biotech has been just exceptional with communication. They have been professional, courteous, and embraced the concept of teamwork with our company. Alta Biotech has brought a sense of relief to my daily operations because I can count on them for a prompt response and to go the extra mile to get the job done. They willingly handled special requests for the specific concentrations of the material and type of vials used for delivering materials needed to support ongoing projects, and still delivered requests on time. I hope to work with Alta Biotech for many years to come.”

- Michael. L., Novartis

“Alta Biotech has helped us time and time again by providing impeccable service. Sean and his team have been expedient and thorough in their work. They are also welcome to suggestions that make our job downstream easier. Customer service is always available and timely in their response to any of our queries. It has been a sincere pleasure to work with them, and we definitely will continue working with them in the future.”

- Amy R., Pharmaceutical Company

“It is my pleasure to refer your DNA prep service. We never had issue with Alta Biotech service. They were always proactive about with our order. Sean continuously work with us to for smooth and easy service, happily took our suggestion and implemented them promptly. We are very happy with their service.”

- Shilpa. K., Novartis

“My lab routinely uses Alta Biotech’s services for both endo-free maxi and gigapreps of AAV plasmids. I have been completely satisfied with their services. As AAV plasmids contain highly homologous sequences, they need careful handling and screening to ensure integrity. Alta Biotech always works with us to follow all of these precautions to make sure the plasmid preps are of excellent quality.”

- C. M., Associate Professor, Harvard Medical School

Service Citations

Coughlin GM. Spatial Biology Tools to Accelerate and Refine Adeno-Associated Virus Engineering and Application Ph.D. Thesis, California Institute of Technology, 2025.32098767

Herre M, Vemuri K, Cedervall J, Nissl S, Saupe F, Micallef J, Lindman H, Maguire CA, Tetz G, Tetz V, Olsson AK. AAV‐mouse DNase I sustains long‐term DNase I expression in vivo and suppresses breast cancer metastasis FASEB Bioadv, 2024 Aug 30;6(10):454–466.

Santoscoy MC, Espinoza P, Hanlon KS, Yang L, Nieland L, Ng C, Badr CE, Hickman S, de la Cruz D, Griciuc A, Elkhoury J, Bennett RE, Shen S, Maguire CA. Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice bioRxiv, 2024 Sep 27:2024.09.25.614546

Park C, Hwang IY, Yan SL, Vimonpatranon S, Wei D, Van Ryk D, Girard A, Cicala C, Arthos J, Kehrl JH. Murine alveolar macrophages rapidly accumulate intranasally administered SARS-CoV-2 Spike protein leading to neutrophil recruitment and damage Elife, 2024 Mar 20;12:RP86764

Waldo JJ. Huntingtin for a Cure Ph.D. Thesis, University of California, Davis, 2024.31301342

Jang MJ, Coughlin GM, Jackson CR, Chen X, Chuapoco MR, Vendemiatti JL, Wang AZ, Gradinaru V. Spatial transcriptomics for profiling the tropism of viral vectors in tissues. Nat Biotechnol, 2023 Sep;41(9):1272-1286.

Cao Y, Hayashi CTH, Zavala F, Tripathi AK, Simonyan H, Young CN, Clark LC, Usuda Y, Van Parys JM, Kumar N. Effective Functional Immunogenicity of a DNA Vaccine Combination Delivered via In Vivo Electroporation Targeting Malaria Infection and Transmission. Vaccines (Basel), 2022 Jul 16;10(7):1134.

Stelekati E, Cai Z, Manne S, Chen Z, Beltra JC, Buchness LA, Leng X, Ristin S, Nzingha K, Ekshyyan V, Niavi C, Abdel-Hakeem MS, Ali MA, Drury S, Lau CW, Gao Z, Ban Y, Zhou SK, Ansel KM, Kurachi M, Jordan MS, Villarino AV, Ngiow SF, Wherry EJ. MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection. Proc Natl Acad Sci U S A, 2022 Apr 26;119(17).

Brenchley JM, Langner CA, DNA vector and uses thereof for detecting HIV and SIV. Patent WO2022140126A1, 2021 Jun 30.

CLS Therapeutics Ltd, Treatment of diseases by hepatic expression of enzymes with deoxyribonuclease (DNase) activity. Patent CN112292453A, 2021 Jan 29

Tseng M, Lambie S, Huynh C, Sanford B, Patel M, Herson P, Ormond DR, Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1. Biomacromolecules, 2021 Apr;41(4):761-770.

Xia Y, He J, Zhang H, Wang H, Tetz G, Maguire C, et al. AAV-mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response. Mol Oncol, 2020 Nov;14(11):2920-2935.

Blocklinger K, Use of Clofibrate to Bypass Nuclear Targeting in the Development of Non-Viral Gene Delivery Systems. Iowa Research Online, 2019

Ackerman D, Fluorescence Technology Development for In Vivo Inflammation Sensing, Cell Contact Labeling, and Targeted Photoablation. Ph.D. Thesis, Carnegie Mellon University, 2019 Aug 5.

Sridhar B, Janczy J, Hatlevik Ø, Wolfson G, Anseth K, Tibbitt M, Thermal Stabilization of Biologics with Photoresponsive Hydrogels. Biomacromolecules, 2018 Mar 12;19(3):740-747.